Ken Shuttleworth's practice, Make, has been appointed along with developer First Base to redesign the site of Greenwich District Hospital in south-east London.
The scheme will create a masterplan and build what current landowner English Partnerships is claiming will be a 'new town centre' for Greenwich.
Make says its proposals, which will include shops, cafés, markets and
residential units, will be 'knitted into the surrounding area'.
The practice and the developer have also vowed that the development will be carbon-neutral.
Philip Dibsdale, English Partnerships area director said: 'We have been working closely with the local community in order to understand what the people of East Greenwich want and need from the new development.
'In selecting First Base I'm confident that we will deliver a highly sustainable mixed-use scheme that will best meet the needs of the community,' he added. by Ed Dorrell