Ken Shuttleworth's practice will be working up a masterplan for the Haringey Heartlands project, which will revamp a former industrial site in the borough.
It is hoped that the site, part owned by National Grid Property and the London Development Agency, will be transformed into a 'vibrant, sustainable and attractive new urban quarter' and the speedy appointment of Make could be seen as a strong signal of intent.
National Grid strategic sites manager, Phil Edwards, said: 'This appointment is great news for this vital regeneration project.
'Ken Shuttleworth and his team have a well-deserved reputation for delivering creative, innovative designs and we look forward to seeing them build upon the excellent work that has already been undertaken.'
Shuttleworth was equally keen to develop the site, which is one of the most important regeneration schemes in the area.
He said: 'We are delighted to have been chosen to work up a masterplan for delivering the Haringey Heartlands area that represents one of the most significant regeneration opportunities in London.'