The Clydesdale is one of three banks allowed to issue its own currency in Scotland, and the launch of the new note coincides with the official opening of the £30 million Exchange development.
The eight-storey building, on the corner of Waterloo Street and Wellington Street, was developed with CALA Properties and houses the bank's Financial Solutions Centre.
CALA's managing director Alasdair McConnell said: 'I am flattered that the building had been noted by Clydesdale Bank.'
This is not the first time a Keppie building has featured on a Scottish note. Back in 1999, to celebrate Glasgow's City of Architecture and Design, Charles Rennie Mackintosh's Herald building - now the Lighthouse - was featured on a £20 note.
Built between 1893 and 1895, the building was designed while the Arts and Crafts master was working for Honeyman, Keppie & Mackintosh.