The cabinet minister with responsibility for heritage, among other things, claimed that the perceived threat to the city's status would come to nothing.
The recent debate was triggered after a group from UNESCO, which looks after World Heritage, visited the city's waterfront area.
The resulting report was less than complimentary about both Sheppard Robson's Mann Island proposals and 3XN's X-shaped proposals for an extension to the National Museum of Liverpool.
The document further emphasised divisions in the city, with some calling for the schemes to be dropped and others insisting that the World Heritage site status should be binned.
But speaking at the RIBA conference in Venice on Friday, Jowell said: 'All the signs are that it will be sorted out.
'Some say it is impossible to add a world-class building without detracting from heritage,' she admitted.
'But of course it's a challenge.'