The mixed-use scheme, for Linden Homes South East, picked up detailed consent following a resubmission.
The project will be made up of 198 apartments, a crèche, office space and a nursing home. It will provide 40 per cent affordable housing.
The scheme - which is on a site opposite the Royal Bushy Park - was specially designed to minimise impact on the neighbouring parkland.
The practice, which has included a number of place-making measures, has also put additional emphasis on environmental concerns.
These include a low provision of parking spaces, a large amount of space for bicycles, solar-heat collectors and a recycling point.