Edaw and Studio Egret West (SEW) were on the shortlist separately - along with Maxwan and MacCormac Jamieson Prichard - to design the 34ha Holt Town Waterside.
The pair will work with a series of other consultants to draw up a 15-year plan to regenerate this part of east Manchester, formerly known as the Bradford Road Triangle.
The joint client body, made up of Cibitas Investments, New East Manchester and Manchester City Council, was keen to appoint both EDAW and SEW after seeing their submissions.
Cibitas executive director Mike Appleton said: 'We were impressed by the thoughtfulness of all the teams we had shortlisted for this commission, but in particular by the EDAW approach and the creativity of SEW's house designs [pictured above].
'Together, we are confident of being able to deliver a whole new neighbourhood that will initiate the next wave of urban renaissance in the UK - bringing back families to our inner cities,' he added.
And EDAW's Manchester design director Mick Timpson said he was delighted to have been appointed to a scheme: 'Where is Manchester's answer to high value, family-orientated city fringe areas like Jesmond in Newcastle or Clifton in Bristol?
'We are excited about the prospects of revolutionising the housing offer of Manchester, by developing new house designs and spaces that give families what they want in the heart of the original modern city,' he added.