Peel Holdings, which owns the Trafford Centre in Manchester and Liverpool's John Lennon Airport, hopes to build its own 60-storey tower on an adjacent site.
The developer believes the King Edward scheme could conflict with its own project, which it aims to become a £300 million centrepiece to its £5 billion docklands scheme.
In a statement, Peel Holdings' development surveyor Ian Pollitt said: ‘Peel has objected, as we believe that if this development was carried out in isolation, it would prejudice the planning of the wider area and thereby impact on the potential significant regeneration benefits.’
Speaking to the Liverpool Daily Post, Y1 Developments said: ‘Y1 has approached Peel Holdings in the past to discuss overall developments for the area but their ideas were not fully worked-up.
‘Y1 is keen to see adjoining development at the industrial estate, but is aware of the ownership and infrastructure difficulties that will make swift progress difficult.’