The A66 Gateway Project contest hopes to attract architects and masterplanners to come up with innovative proposals to revamp the public realm at the Cargo Fleet transport interchange site in the east of the town.
If successful, Middlesbrough Council hopes that the 'treatment developed and prototyped' on this plot could be used throughout the 'A66 roadscape' across the town.
Up to five shortlisted practices will be invited to go through to the final design phase of the contest, which is being organised by the RIBA's competition office.
Each of these five finalists will be handed a £3,000 honorarium to help them develop a full design presentation.
The deadline for entries is 8 January 2007.