The centre, on Portland Street, will start welcoming the public again on 20 January with a new team behind its show.
CUBE was closed last year when it faced a financial crisis, a problem so significant that high-profile director Graeme Russell resigned.
Under its previous guise the centre was largely independent, but its present incarnation will see it controlled by Salford University's Centre for Construction Innovation, Manchester City Council and Renew Northwest.
The first show - which will run until 18 March - is called Future Landscapes Under Construction, and will feature schemes from the area such as Ian Simpson Architects' Beetham Tower and Will Alsop's Chips building.
The gallery is yet to decide whether it will replace Russell, who is currently working in a limited capacity for the RIBA.